pDC hematopoiesis is blocked by γ-secretase inhibition. (A) Representative fluorescence-activated cell sorter (FACS) analysis showing the modulation of BDCA-2 and CD14 expression by the γ-secretase inhibitor DAPT (γSI) or DMSO control. (B) Average percentages and total numbers of BDCA-2⁺ CD123⁺ cells ± SD produced in 3 independent experiments in the presence or not of γ-secretase inhibition with concomitant analysis of the changes in percentages of CD56⁺ NK cells and CD14⁺ monocytes in these cultures.