Unsupervised hierarchical clustering of samples reveals discrete methylation groups on the basis of cytogenetic abnormalities. Distinct clades are highlighted and labeled A-H. Samples are color coded with cytogenetic data: cell type, translocation, TC, and UAMS classifications and colors are as per the key. Other cytogenetic data are coded as red for present, green for absent, and white for no data. Heatmap key indicates β-value methylation level. UAMS subgroups: CD-1/CD-2, cyclin D1 subgroups; HY, hyperdiploid; LB, low bone disease; MF, MAF; MS, MMSET/FGFR3; PR, proliferation. TC subgroups: D1, cyclin D1; D2, cyclin D2; D3, cyclin D3; MAF, MAF/MAFB; MMSET, MMSET/FGFR3 MAF, v-maf musculoaponeurotic fibrosarcoma oncogene homolog.