Typical appearance of VWF multimers in AVWS compared with von Willebrand disease. (A) Congenital von Willebrand disease: lane 1 indicates type 2A; lane 2, type 2B; and lane 3 normal plasma (NP). Cardiovascular disorders: lane 4 indicates aortic valve stenosis; lane 5, LVAD; and lane 6, patient on extracorporeal membrane oxygenator (note decrease of HMW multimers). (B) Lymphoproliferative disorders: lanes 1 and 2 indicate IgG-MGUS (note decrease of HMW multimers and relative increase of the lower satellite band within triplets); and lanes 4 to 6, IgM-MGUS (note blurred structure of triplets and loss of HMW multimers in lane 6). (C) Myeloproliferative disorders: lanes 2 to 4 (note variable decrease of HMW multimers and disturbed triplet structure). Lanes have been arranged from different gels and fit for size and staining intensity.