Hsp90 inhibitors reduce dermal neutrophil infiltration. Semiquantitative scoring of dermal neutrophil infiltration ranging from 0 (no infiltration) to 3 (severe infiltration) in mice treated with vehicle versus 17-DMAG (A) or vehicle vs TCBL-145 (B) at the end of the 6-week treatment period. Values are means ± SEM of ≥ 6 mice per group. *P < .05. (C) Representative histopathology specimens obtained from the ears of mice injected with vehicle or 17-DMAG by the end of the treatment period. In contrast to 17-DMAG–treated mice, vehicle-injected mice showed dermal-epidermal separation and stronger dermal inflammatory infiltrate dominated by neutrophils (magnification, 400×).