Hsp90 inhibitors suppress autoantibody production. Mean relative titer changes of autoantibodies directed against the dermal-epidermal junction as detected by indirect immunofluorescence microscopy using normal murine skin as a substrate after the 6-week treatment period with vehicle versus 17-DMAG (A) or vehicle vs TCBL-145 (B). Values are means ± SEM of ≥ 6 mice per group. *P < .05.