American Society of Hematology

Figure 2

$Figure 2. Hypoxia/normoxia protocol to study effects of ARC5690 on sickle RBC and leukocyte adhesion. SCD mice were injected with saline, ARC5690 or ARC5694. Two and one-half hours after injection, mice were subjected to 1 hour of hypoxia (FiO2 = 0.12) followed by 1 hour of normoxia in room air (FiO2 = 0.21), and intravital studies were then initiated. During surgery, mice were supplemented with 30% O2. FiO2 indicates fraction of inspired oxygen in a gas mixture.$

Hypoxia/normoxia protocol to study effects of ARC5690 on sickle RBC and leukocyte adhesion. SCD mice were injected with saline, ARC5690 or ARC5694. Two and one-half hours after injection, mice were subjected to 1 hour of hypoxia (FiO₂ = 0.12) followed by 1 hour of normoxia in room air (FiO₂ = 0.21), and intravital studies were then initiated. During surgery, mice were supplemented with 30% O₂. FiO₂ indicates fraction of inspired oxygen in a gas mixture.

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