Cloning of the t(6;14)(p25;q32) translocation. (A) Chromatograms and sequences of the different chromosomal junctions of the IGHSμ/EXOC2 translocations in cases 3 and 5. The sequence of IGHSμ is shown according to GenBank accession no. NG_001019.3 and of EXOC2 according to GenBank accession no. NT_007592.15. The der(6) genomic breakpoints were located downstream of exon 22 (case 3) and exon 23 (case 5) of EXOC2 gene at 482 370 and 464 205 bp from 6pter (UCSC, NCBI Build 36.1/hg18). (B) FISH analysis shows IRF4 breaks in case 3. (C) FISH image on metaphase shows an IGK/IRF4 fusion in case 15.