Regional association plots. (A) 6q25.1 (B) 17p11.1 P values are from the Cochran-Armitage trend test. ● represents genotyped SNPs in the discovery set; and ○, genotyped SNPs in the validation set. The rs numbers of the validated SNPs are provided in Table 1. Gray shaded circles represent imputed SNPs; and gray line, recombination rates (estimated using the HapMap combined data). Arrows indicate the locations of genes. (Bottom panel) A linkage disequilibrium map based on r² values computed using the HapMap JPT + CHB data.