Figure 6
Cellular infiltrates in liver sections 2 hours after vector administration (representative examples). (A-G) Neutrophils. (H-N) Macrophages. (O-U) NK cells. (A) C3H-OuJ control mice injected with PBS. Other panels shown are for hepatic gene transfer with ssAAV2-hF.IX in C3H-OuJ (B, I, P), scAAV2-hF.IX/TLR9i ODN in C57BL/6J (C, J, Q), scAAV2-GFP/GldCl3-treated C3H-OuJ (D, K, R), scAAV2-hF.IX in C3H-OuJ (E, L, S), scAAV8-GFP in C3H-OuJ (F, M, T), or (G) scAAV2-hF.IX/TLR9 control-ODN in C57BL/6J mice (G, N, U). Original magnification: ×40 (neutrophils) or ×20 (macrophages and NK cells).
