Differential depletion of CD4⁺ T cells and pDCs in HIV-infected DKO-hu mice. (A) Human CD4⁺ T cells were depleted by HIV-1 infection. Total BM cells from HIV-infected DKO-hu mice were analyzed by FACS. The numbers in each plot represent the percentage of CD4⁺ T cells of total CD3⁺ T cells. (B) Human pDCs were not depleted. Total human CD45⁺ cells were analyzed for CD4⁺CD123⁺ pDC. The number is the percent pDCs of total human CD45⁺ cells. (C) Summarized data of human CD4⁺ T cells and pDCs in the BM. (D) Summarized data of CD4⁺ T cells and pDCs in the spleen. Student t test was used to calculate P values.