Use of TLR4 and TLR7/8 agonists in combination results in the synergistic release of IL12p70 during DC maturation. Immature DCs were stimulated with the indicated maturation reagents and IL12p70 production was quantified by ELISA of DC culture supernatants. Data points indicate values for separate donors performed in independent experiments and lines indicate means ± SEM. **Statistical significance with P values shown.