IVC stenosis induces formation of human-like deep vein thrombi in WT mice. Stenosis of IVC was applied in WT mice, and a typical thrombus formed in 48 hours is presented (A). “White” (W) and “red” (R) regions of the thrombus are indicated. Bar, 500 μm. (B-C) A thrombus obtained in the stenosis model was longitudinally cut and stained for a platelet marker (αIIb, green), fibrinogen/fibrin (red), and counterstained for nuclei (blue). Combined images of the thrombus regions remote from (B) and close to (C) the ligation is shown. Unstained dark area is rich in red blood cells. Bar, 50 μm. Representative photographs are shown, n = 3.