Figure 1
Figure 1. Effects of Dll4/Notch genetic and pharmacologic modulation on oxygen-induced vaso-obliteration. (A-B,D-E,G-H,J-K) GS lectin staining of the retinal vasculature in 12-day-old (A,D,J) or 10-day-old (G) control mice and in Dll4+/− (B), Dll4+/COIN;Rosa26-CreERT2+/− treated with tamoxifen, and Nrarp−/− (K) mice that were exposed to high oxygen for 5 days and WT mice treated with Dll4-Fc and exposed to high oxygen for 1 day (H). (C,F,I,L) Quantification of the avascular area. Decreased vaso-obliteration in Dll4+/− (C) and Dll4+/COIN;Rosa26-CreERT2+/− (F) mice compared with littermate controls as well as in mice treated with Dll4-Fc (I) compared with control mice treated with Fc. (L) Increased vaso-obliteration in Nrarp−/− mice compared with WT littermates. Percentages indicate changes in avascular areas compared with corresponding control animals. Original magnification, ×20.

Effects of Dll4/Notch genetic and pharmacologic modulation on oxygen-induced vaso-obliteration. (A-B,D-E,G-H,J-K) GS lectin staining of the retinal vasculature in 12-day-old (A,D,J) or 10-day-old (G) control mice and in Dll4+/− (B), Dll4+/COIN;Rosa26-CreERT2+/− treated with tamoxifen, and Nrarp−/− (K) mice that were exposed to high oxygen for 5 days and WT mice treated with Dll4-Fc and exposed to high oxygen for 1 day (H). (C,F,I,L) Quantification of the avascular area. Decreased vaso-obliteration in Dll4+/− (C) and Dll4+/COIN;Rosa26-CreERT2+/− (F) mice compared with littermate controls as well as in mice treated with Dll4-Fc (I) compared with control mice treated with Fc. (L) Increased vaso-obliteration in Nrarp−/− mice compared with WT littermates. Percentages indicate changes in avascular areas compared with corresponding control animals. Original magnification, ×20.

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