CD48 loss causes the progenitor compartment to lose equilibrium. (A) CD48's expression throughout the hematopoietic progenitor compartment including the LT-HSCs, ST-HSCs, multipotent progenitor (MPP), common lymphoid progenitor (CLP), common myeloid progenitor (CMP), granulocyte/monocyte progenitors (GMP), and the megakaryocyte/erythrocyte progenitors (MEP). (B) The BM of the CD48^−/− 8- to 12-week-old mice show significant differences in the proportions of short-term progenitors with the long-term HSCs (SP^KLS CD34⁻Flk2⁻) remaining stable as determined by a Student t test.