CIP2A plays a key role in regulating PP2A in CML cells. K562 cells were treated with CIP2A siRNA for 72 hours (n = 5). The effects are shown on: CIP2A protein levels as a control (A), BCR-ABL1 activity as assessed by the pCrkL/CrkL ratio (B), PP2A and phosphorylated PP2A (C-D), SET (E), and JAK2 (F). c-Myc phosphorylation at serine 62 and total c-Myc protein (G-H).