Schematic representation of the interplay between Myc, miR-34a, and FoxP1 during malignant transformation of low-grade gastric MALT lymphoma to gDLBCL. Myc overexpression can be caused by chromosomal translocations involving MYC and IG loci or other genetic abnormalities or by posttranscriptional regulation through miRNAs such as members of the let7 family and miR-34a (as first shown by Christoffersen et al³² ). Antigen dependence is lost during malignant transformation.