Prognostic impact of complete remission confirmed by CT scan. Progression-free survival for all 3 studies (A) and for the CLL8 trial (B) (FC vs FCR) for patients with CRs additionally confirmed by CT scans versus CRs confirmed by clinical examination and bone marrow biopsy only. In all studies median progression-free survival was significantly longer in patients with additionally performed CT scans in comparison with those without (P = .04). The CLL8 trial evaluating the role of chemoimmunotherapy (B) showed no difference between both CR definitions (P = .44)