MeDIP analysis of DNA methylation within the Aiolos promoter containing a CpG rich region. (A) Aiolos promoter methylation status was analyzed in Daudi and U937 human cell lines, positive and negative for Aiolos expression, respectively. CpG island is marked in gray. (B) Aiolos promoter methylation status was analyzed in CLL patients and HD. The graph shows the average percent immunoprecipitation with SEM for HD (n = 3) and CLL patients (n = 3) calculated for each position. GAPDH and TSH2B loci were used as negative and positive control for MeDIP, respectively.