Trend test P values (as −log₁₀values; leftyaxis) are shown for SNPs analyzed in GWA study. Recombination rate is shown across the region with the solid line (right y axis). Triangles indicate imputed SNPs and circles indicate observed SNPs. Coloring (black, light gray, white) shows the extent of LD between each SNP and rs391525. Black: r² ≥ 0.75; light gray: 0.25 ≤ r² < 0.75; white: r² < 0.25. (A) Association results of the 16q24 locus across a 60-kb region between all discovery CLL cases and controls. (B) Association results of the 6q21.3 locus between the discovery familial CLL cases and controls.