T_HS cells from the blood of patients with L-CTCL were clonal proliferative CD4⁺ CCR4⁺ memory T cells expressing central memory T-cell markers. The phenotype of high-scatter (red) and low-scatter (black) T cells of 2 patients with L-CTCL are shown. In both patients, T_HS cells virtually all clonal CD4⁺ cells expressing high levels of CCR4 and variable levels of CLA. Most T_HS cells coexpressed the T_CM cell markers L-selectin and CCR7 and retained CD27 expression. Two representative patients are shown; similar results were found in 6 additional patients with L-CTCL. In gated histograms, the % total cells in each quadrant are shown.