Relationship between CCL3, CCL4, and the time from diagnosis to initial therapy. (A) Kaplan-Meier curves show the probability of treatment-free survival according to the time since diagnosis. CLL patients are divided into groups of patients with low or high CCL3 (left-hand curve) or CCL4 (right-hand curve) plasma levels. These categories are based on CCL3 and CCL4 cutoff levels that correspond to the median CCL3 and CCL4 concentrations in our population (Table 2); the respective cutoff levels are displayed next to each of the curves. (B) Kaplan-Meier curves that display the proportion of untreated patients in 4 CLL subgroups, based on their CCL3 and CCL4 levels. Patients with high CCL3 (≥ 10 pg/mL) and low or high CCL4 show lower probabilities of treatment-free survival than patients with low levels of CCL3 (< 10 pg/mL) and high or low CCL4 levels.