S100A10^−/− mice have impaired ability to clear induced fibrin clots. WT and S100A10^−/− mice were injected with ¹²⁵I-fibrinogen and batroxobin. After 2 hours, tissues were collected, weighed, and radioactivity was measured with a γ counter. The data are expressed as counts per gram of tissue. Statistical analysis was performed with the Student t test, and the data are expressed as the mean (±) SEM of 6 independent experiments (*P < .1, **P < .01, ***P < .001). Figures were generated with Adobe Photoshop CS3 Version 10 (Adobe Systems Incorporated).