Somatic mutations in ETV6. (A) Distribution of somatic sequence mutations in ETV6. The N-terminal pointed (PNT) is involved in protein-protein interactions with itself and other proteins, whereas the C-terminal ETS domain (red) is involved in DNA binding. (B) Single and double mutations in ETV6. The genomic region in display is chromosome 12:11 619 584–12 112 117 (genome build hg18). Each row represents a sample with somatic alterations. Gray lines indicate deletions; and black lines, homozygous deletions. Sequence mutations are shown as vertical black boxes.