SNP 6.0 array–based lesion cutoffs and IgV_H status or ZAP70 status and OS in CLL (bivariate analysis; Kaplan-Meier plots). Previously untreated patient group was analyzed from trial enrollment (A-C) IgV_H status and various SNP 6.0 array–based lesion cutoffs and (D-F) ZAP70 status and various SNP 6.0 array–based lesion cutoffs.