Overall survival based on vitamin D insufficiency in both cohorts. (A) OS among Rai 0 patients (n = 259). (B) OS of IGHV-unmutated patients based on vitamin D insufficiency (n = 230). (C) OS of ZAP-70–positive patients based on vitamin D insufficiency (n = 185). (D) OS of patients with standard-risk FISH (eg, normal, trisomy 12, 13q−) based on vitamin D insufficiency (n = 393).