Schematic representation of the NUP98 protein. Blue lines indicate GLFG repeats, the dark blue box indicates the GLEBS binding domain (GBD), and green and red boxes indicate the nucleoporin RNA-binding site and autoproteolytic cleavage site, respectively. Known NUP98 interacting factors are indicated; transcriptional coactivator CBP/p300 (purple) and the TAP transport cofactor (orange) bind the GLFG repeats. The APC/RAE1 complex (light blue) binds the GBD.