Impact of IDH2 mutant status on outcome. (A) Kaplan-Meier curves for OS stratified by IDH2 and IDH1 mutant status. OS in (B) NPM1^WT and (C) NPM1^MUT subgroups. (D) Mantel-Byar analysis for the effect on overall survival of an IDH2^R140 mutation stratified by NPM1 and FLT3/ITD mutant status. (E) OS in FLT3/ITD^WTNPM1^MUTIDH2^R140 patients compared with those with favorable-risk cytogenetics. (F) Relapse in FLT3/ITD^WTNPM1^WTIDH2^R172 patients compared with those with adverse-risk cytogenetics.