Transfusion-related fatalities reported to the FDA.¹⁴  The 3 leading causes of known and reported allogeneic blood transfusion-related deaths, based on data reported passively to the US FDA over 32 years (1976-2007). For each of the 5 periods for which data have been made available, the figure shows the mean annual number of deaths deemed to be due to TRALI, transfusion associated sepsis (TAS), or ABO hemolytic transfusion reactions (HTRs), along with the mean total number of deaths reported to the FDA plotted on a logarithmic scale. Deaths reported to the FDA include donor fatalities, recipient fatalities in which allogeneic blood transfusion (ABT) was not deemed to be the probable or major cause of death, and recipient fatalities due to TRALI, TAS, ABO HTRs, and other transfusion complications. Data on TRALI and TAS are not available for the period 1996 to 2000. (Reprinted with permission.)