Atp4a^sublytic causes parietal cysts and achlorhydria. (A) Stomachs of age- and sex-matched sublytic and wild-type mice. (B) Sections of stomachs from sublytic and wild-type mice stained with H&E. Numerous parietal cell cysts developed in the gastric mucosa of sublytic mice. Arrow indicates parietal cells. (C) pH of the gastric contents of sublytic and wild-type mice. Samples were collected 45 minutes after subcutaneous injection of histamine HCl. Each point represent an individual mouse.