TFS of 449 patients with CLL according to the sFLC assay. Kaplan-Meier curves show the 3-year probability of remaining treatment-free for CLL cases subdivided into 3 groups based on their normal [normal sFLC(κ/λ)] or abnormal κ or λ sFLC ratio. The 3-year TFS was significantly lower in patients with κ or λ sFLC(κ/λ).