Comparison of cytogenetic risk and total sFLC. (A) CLL patients (n = 303), stratified by cytogenetic risk (low risk, normal and 13q14.3; intermediate risk, trisomy 12; high risk, 11q22.3 and 17p13.1) groups showed a significant correlation with sFLC(κ + λ) cut-off value (60.6 mg/mL). Forest plots indicating (B) an abnormal sFLC(κ/λ) (HR = 2.0, 95% CI, 1.3-3.1) and (C) sFLC(κ + λ) above the cut-off (HR = 2.8, 95% CI, 1.7-4.5) retained an independent association with TFS together with cytogenetics, ZAP-70 expression, and Binet stage in Cox multivariate models.