Skewed proportions of CD4⁺ T_N, T_CM, and T_EM cells in FL. (A) Shown are representative plots of healthy donor PBMCs, reactive TN, NLN, RLN, and FL defining CD4⁺ T_N (CD45RA⁺), T_CM (CD45RA⁻CCR7⁺), and T_EM (CD45RA⁻CCR7⁻) populations (numbers above each gate are representative of the percentage of total CD4⁺ T cells). Proportions of T_N, (B), T_CM (C), and T_EM (D) are expressed as the percentage of the total CD4⁺ T cells in the indicated tissues. Also shown are the proportions of T_CM that are either CXCR3⁻ or CXCR3⁺ (E) or the proportions of T_EM that are either CXCR3⁻ or CXCR3⁺ (F). Triangles represent values for individual samples, and the rectangles represent averages for each tissue type expressed as a percentage of the total CD4⁺ T cells (B-D); T_CM cells (E-F), or T_EM cells (G-H). *P < .05, **P < .01, and ***P < .001 compared with FL.