Percentage of viable B-ALL cells after culture alone or coculture with hBM-MSCs and the specific relative cell viability (%) of B-ALL cells cultured alone or cocultured with hBM-MSCs in presence of increasing concentrations of GSI XII. (A) Percentage of viable B-ALL cells cultured alone or cocultured with hBM-MSCs at 10/1 ratio for 3, 7, and 28 days. (B-C) Specific relative cell viability (%) of B-ALL cells was evaluated by culturing alone or coculturing B-ALL cells with hBM-MSCs at 10:1 and 1:1 ratios in presence of increasing concentrations of GSI XII for 3 days. Statistical analysis was carried out by using the Student t test and 1-way ANOVA, Holm-Sidak test. ***P < .001. Data were represented as the mean ± SD of 10 independent experiments.