In vivo targeting of DCs with nanodevice containing immunodominant antigens and TLR agonists. Biodegradable poly (lactic-coglycolic) acid (PLGA) nanoparticles (NPs) effectively deliver antigen and TLRLs to DCs and trigger endocytosis through C-type Lectin receptors and accelerate antigen processing and presentation through TLR signaling.