Longitudinal analysis of uniformly treated CLL patients. Twelve cases of progressive CLL were analyzed by various techniques (aCGH, WES, and TDS) before and after therapy. The horizontal axis represents the timeline (in months) of sample collection. Each patient is presented as string, and the circles represent samples collected and the type of analysis performed. aCGH, array comparative genomic hybridization; TDS, targeted deep sequencing; WES whole exome sequencing.