Figure 1
Figure 1. Genetic elimination of coagulation fXIIIA results in diminished CIA incidence and severity. (A) The percentage of male mice with macroscopic arthritis in the paws is shown for the 3-week evaluation period after the second CII immunization. Note that approximately 20% of fXIIIA−/− mice remained arthritis-free based on visible inspection through the CIA study period. Kaplan-Meier log-rank analysis. (B) The median arthritis index revealed a significant diminution in number of arthritic joints in the absence of fXIIIA. (C) The median arthritis severity for the same cohort of mice revealed a significant reduction in paw swelling for CIA challenged fXIIIA−/− mice (n = 18 in fXIIIA+/+ group and n = 17 in fXIIIA−/− group). Mann-Whitney U test. *P < .05; **P < .01 (B-C).

Genetic elimination of coagulation fXIIIA results in diminished CIA incidence and severity. (A) The percentage of male mice with macroscopic arthritis in the paws is shown for the 3-week evaluation period after the second CII immunization. Note that approximately 20% of fXIIIA−/− mice remained arthritis-free based on visible inspection through the CIA study period. Kaplan-Meier log-rank analysis. (B) The median arthritis index revealed a significant diminution in number of arthritic joints in the absence of fXIIIA. (C) The median arthritis severity for the same cohort of mice revealed a significant reduction in paw swelling for CIA challenged fXIIIA−/− mice (n = 18 in fXIIIA+/+ group and n = 17 in fXIIIA−/− group). Mann-Whitney U test. *P < .05; **P < .01 (B-C).

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