Reduced inflammatory cytokine expression in CIA-challenged fXIIIA-deficient mice. Quantitative RT-PCR analysis of messenger RNA levels for inflammatory cytokines IL-6 (A), IL-1β (B), TNFα (C), and IL-10 (D) in the hind paws obtained from unchallenged (control, n = 6 per genotype), day 28 (n = 9 per genotype), and day 42 (n = 10 per genotype) of fXIIIA^+/+ and fXIIIA^−/− mice. Data are expressed as average fold change over unchallenged fXIIIA^+/+ group with error bars denoting standard error of the mean. P < .001 (A); Data analyzed by 2-way analysis of variance, followed by Student-Newman-Keuls posthoc test.