Effect of Δ¹²-PGJ₃ treatment on leukemia induced by transplanting FV-induced LSCs expanded in vitro into FV-resistant Stk^−/− mice. (A) Photograph of spleens from Stk^−/− mice 7 weeks after transplantation with FV-LSCs followed by treatment with vehicle, 0.05 mg/kg, or 0.025 mg/kg Δ¹²-PGJ₃ for 1 week. (B) Spleen weights are shown for the conditions in panel A. n = 5 per group, *P < .05 compared with the vehicle-treated group. (C) WBC counts in LSC-transplanted Stk^−/− mice treated with indicated amounts of Δ¹²-PGJ₃ or vehicle control. n = 5 per group. *P < .05 compared with vehicle-treated group. (D) M34⁺Kit⁺Sca1⁺ cells in Stk^−/− mice transplanted with LSCs. Spleen cells that were isolated and gated on Kit⁺, expression of M34 and Sca1 is shown. n = 5 per group.