Lack of correlation between mRNA expression of antiapoptotic BCL-2 family members, individually or combined, and response to ABT-737. Quantitative RT-PCR was used to study antiapoptotic BCL-2 family mRNAs. Expression values of each antiapoptotic transcript or their combinations were plotted against cell viability after ABT-737 treatment. RNA expression for each transcript was normalized to that obtained in lymphocytes isolated from 6 healthy donors. (A) BCL-2, (B) MCL-1, (C) BFL-1 (BCL2A1), (D) BCL-B, (E) BCL-XL, (F) BCL-W, (G) BCL-2 + BCL-XL + BCL-W, and (H) MCL-1 + BFL-1 + BCL-B expression. Spearman correlation (r) and P values are shown.