Rps19 deficiency results in impaired proliferation of hematopoietic progenitors and increased apoptosis. shRNA-B mice were induced for 10 days with doxycycline followed by FACS sorting of (A) preMegE progenitors (n = 180 single-cell cultures), (B) preCFU-E/CFU-E progenitors (n = 240 single-cell cultures) or (C) 1000 preGM/GMP progenitors (n = 3-6 per genotype) into supportive liquid cultures with or without doxycycline. (D) Cell cycle analysis of early (CD71⁺ Ter119⁺) and late (CD71^low Ter119⁺) erythroblasts in induced shRNA-B mice (n = 4-6 per genotype). Dean-Jett-Fox model was used to calculate percentages of cells in G₁/G₀, S, and G₂/M phases (shown in green). (E) TUNEL staining of whole bone marrow cells from shRNA-B mice after 10 days (n = 2-3 per genotype) or 7 weeks (n = 3 per genotype) of doxycycline administration. Error bars represent SD.