CCL17/TARC and CCL22/MDC changes. Shown are CCL17/TARC and CCL22/MDC changes from pretherapy cycle 1 day 1 (C1D1) and cycle 1 day 15 (C1D15) for responders (CR/PR/SD ≥ 6 months) and nonresponders (SD < 6 months, PD). Box-whisker plots depict pretherapy and C1D15 plasma CCL17 or CCL22 concentrations. P values were determined using the Wilcoxon signed rank test. There was no significant difference between C1D1 and C1D15 in nonresponders.