Genes enriched in rM cells compared with naive and pro-inflammatory macrophages. An FDR of 0.05 and fold difference of 1.5 revealed (A) 342 genes up- and down-regulated in rM compared with pro-inflammatory (10 mg zymosan) and naive macrophages, a sample of the most differentially expressed genes presented in panel B. The software package Expander Version 5.1 detected (C) 191 probe sets significantly up-regulated in rM cells with these gene sets enriched for (D) aspect of antigen uptake/presentation and immune function. (E) A list of the genes involved in antigen processing and presentation of peptide/polysaccharide via MHC class II (GO:0002504), immune system process (GO:0002376), response to stimuli (GO:0050896), and regulation of T-cell activation (GO:0050863). There was significant enrichment for (F) 154 down-regulated probe sets with their significantly enriched functional classespresented in panel G. Genes involved in developmental processes (GO:0032502) are listed in panel H.