Schematic representation of the animal model of VT (EIM) to study antithrombotic and prothrombotic conditions. (A) IVC (large circle) and the thrombus (small circle). (B) The EIM generates 80% occlusion of the vein wall lumen in control animals by day 2 using 250 µA over 15 minutes. An antithrombotic intervention will reduce the thrombus size at the same time point (experimental condition). (C) The modification introduced by Banno et al (200 µA over 10 minutes) generates a smaller thrombus size in the control animals by day 2, allowing for prothrombotic interventions that will increase the thrombus size at the same time point (experimental condition).