Functional connectivity map of AUBPs in hematopoiesis and leukemogenesis. The major regulatory interactions between AUBPs (gray nodes), miRNAs (blue nodes), and oncoproteins/tumor suppressor proteins (pink/orange nodes) are shown as a network graph in which edges represent experimentally validated functional connections that have been manually curated from the literature and are described in the text. In most cases, the directionality of positive (→) or negative (⊣) regulatory interactions is known. Solid line edges represent interactions documented in normal/malignant hematopoietic cells; and dashed-line edges, interactions identified in other cell types that are probable to occur in hematopoietic cells. The network graph shows an organic layout view constructed using Cytoscape Version 2.8.0.