Impact of NOTCH1/FBXW7 mutational status on outcome of adult T-ALL patients treated on the LALA-94 or GRAALL trials. (A) EFS and (B) OS. Kaplan-Meier analyses showing a significantly lower risk of event or death for patients with mutated NOTCH1 and/or FBXW7 (black line) compared with NOTCH1/FBXW7 unmutated patients (dashed line).