Effect of PKK and fXII ASOs on stenosis-induced inferior vena cava thrombosis. Male BALB/c mice were treated subcutaneously with PKK or fXII ASO for 3 weeks at indicated doses (n = 6-8 per treatment group). Vena cava thrombosis was induced by combination of reduced blood flow with minor endothelial damage. Twenty-four hours after thrombosis induction thrombi were collected, fixed in formalin, weighed (A-B) and photographed (C-D). Thrombus weight relative to PBS control mice was calculated (A-B). FXI ASO was used as a reference antithrombotic drug (B,D). Comparison of effects of PKK and fXII protein inhibition in stenosis-induced vena cava (IVC) thrombosis (E). *P ≤ .05, **P ≤ .01 and ***P ≤ .001 compared with untreated control.