Effect of PKK and fXII ASO treatments on bleeding. Effect of PKK (A) and fXII (B) antisense treatment at indicated doses on tail bleeding was evaluated in male BALB/c mice (n = 10 per treatment group). FII ASO treatment at indicated dose was shown to cause increased bleeding and was used as reference drug (A-B). *P ≤ .05, **P ≤ .01 and ***P ≤ .001 compared with untreated control.