Distribution of sufficient (> 100 U/L; grey bars), borderline (50-100 U/L; dark grey bars), and insufficient (< 50 U/L; black bars) ASE activity in serum samples with Ab levels < 20 AU/mL, 20-200 AU/mL, and > 200 AU/mL collected during a period of 14 days after the administration of 1000 U/m² pegylated E coli ASE. The actual numbers of samples are given in the stacked bars.