Figure 3
Plg-RKT regulates cell-surface plasminogen activation by uPA. Plasminogen activation was determined as described in “Plasminogen activation assay” in the presence of different concentrations of U937 cells as indicated and in the presence of 170nM of either anti–Plg-RKT mAb 7H1 (■) or mouse IgG2a isotype control (□). Cell-dependent plasminogen activation is shown after subtracting plasminogen activation in the absence of cells. **P < .001 compared with the corresponding isotype control.
