Synergy between panobinostat and decitabine in luminometric assays. (A) Combination of panobinostat and decitabine in Ly1 DLBCL line after 72 hours of incubation. Values represent means expressed as percentages compared with the untreated control; error bars represent SD. (B) Combination of panobinostat and decitabine in the Ly10 DLBCL line after 72 hours of incubation. Values represent means expressed as percentages compared with the untreated control; error bars represent SD. (C) RRR and CI values for combination of decitabine and panobinostat in Ly1 DLBCL line after 72 hours of incubation. Also shown is a normalized isobologram. (D) RRR and CI values for combination of decitabine and panobinostat in the Ly10 DLBCL line after 72 hours of incubation. Also shown is a normalized isobologram. (E) RRR values across the spectrum of DLBCL lines for 4 explored HDACIs in combination with decitabine.